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Immediately after possibly oral or intravenous administration, sildenafil is excreted as metabolites predominantly inside the feces (approximately 80% of administered oral dose) and also to a lesser extent from the urine (about thirteen% of your administered oral dose).
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The concomitant administration of your protease inhibitor ritonavir substantially raises serum concentrations of sildenafil (11-fold rise in AUC). If VIAGRA is prescribed to sufferers using ritonavir, warning really should be used. Information from topics subjected to superior systemic levels of sildenafil are minimal.